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MIP4CELL

Contact person: Guoqing Pan
Responsible: Guoqing Pan
Funding: Horizon 2020 Marie Skłodowska-Curie Actions
Timeframe: 2016-03-01 -- 2018-02-28
Research programme: Biofilms Research Center for Biointerfaces
Faculty/Department: Faculty of Health and Society, The Department of Biomedical Science
Subject: Naturvetenskap

Tissue engineering or regenerative medicine, with its ultimate aim of developing true human replacement parts, has recently made enormous progress. The field refers to the use of human cells to replace or regenerate tissues or organs. Ideally, biomaterials for tissue engineering should efficiently mimic functionalities of the natural extracellular matrix (ECM).
Hence surfaces of biomaterials should be engineered for dynamic control of cell behaviour. The objective of this project is to exploit molecular imprinting as a dynamic methodology for biofunctionalization and tissue engineering. Building on our previous proof of concept demonstration of systems for cell sheet harvesting, we expect to hereby obtain dynamic biofunctionalization of surfaces and overcome limitations of currently used methodologies (e.g. ligand leaching in noncovalent approach, loss of bioactivity in covalent approach, and lack of means for dynamic control of cells adhesion in both). 

Senast uppdaterad av Magnus Jando