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Bacterial acid tolerance

Projektets titel
Bacterial acid tolerance – A new target for fluoridated milk in caries prevention.

Sammanfattning
The aim of the project is to investigate whether caries is caused by specific disease-inducing activities in dental biofilms and if caries can be prevented by interfering with the development of aciduric phenotypes using fluoride in milk.  We have so far recruited 88 adolescents (12-years-old in 2012) who are currently participating in the clinical trial: 41 subjects at the Public Dental Health Clinic in Alvesta and 47 subjects at the Public Dental Health Clinic in Sölvesborg.

Thus 88 participants are presently drinking milk supplemented with fluoride/control solution on a daily basis. Therefore we consider the project to be well on track with the protocol.Caries risk assessment performed at the Clinics shows that 15 % of the participants had previous caries experience (high caries risk) in Alvesta and 34% in Sölvesborg. Therefore, we judge the caries prevalence to be sufficiently high to enable us to see the effect of the fluoride intervention.Plaque samples for determination of acid tolerance from the 88 participants have been analysed. There has been enough material in all samples to be able to determine the acid tolerance of the bacteria. In Alvesta 71% of the participants had plaque acid tolerance score values of 1 or 2 indicating a low acid tolerance. For Sölvesborg the same figure was 51%.

Medverkande
Gunnel Svensäter Professor Faculty of Odontology, Malmö
Julia Davies Professor Faculty of Odontology, Malmö
Madeleine Rohlin Professor Faculty of Odontology, Malmö
Björn Axtelius Professor Faculty of Odontology, Malmö
Jessica Neilands Researcher Faculty of Odontology, Malmö
Anna Senneby Researcher Faculty of Odontology, Malmö
Ulrika Troedsson Technician Faculty of Odontology, Malmö

Medverkande kliniker
Christina Stebring-Franzon Ansvarig
Maria Hilding
Carina Norberg Ansvarig
Ingela Franzén

Senast uppdaterad av Daniel Bengmark