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Regulation of Surface Protein Presentation on Streptococcus gordonii

Kontaktperson: Gunnel Svensäter
Ansvarig: Gunnel Svensäter
Medarbetare: Mark Herzberg, Univ of Minnesota, USA, Julia Davies, Claes Wickström och Agnethe Henriksson
Finansiär: NIH
Tidsram: 2016-07-01 -- 2020-06-30
Fakultet/institution: Odontologiska fakulteten
Ämne: Odontologi

We have shown that interaction of the commensal oral bacterium Streptococcus gordonii with salivary mucins results in presentation of new adhesins on the bacterial surface that enhance mucin-binding, thus ensuring its persistence in the oral cavity. We are using proteomic and transcriptomic approaches to identify the mechanisms by which these bacteria “sense” their surroundings and transduce the signal intracellularly allowing them to adjust their expression of adhesins. 

Senast uppdaterad av Magnus Jando